Renal function and 35S-furosemide metabolism
نویسندگان
چکیده
منابع مشابه
The furosemide stress test to predict renal function after continuous renal replacement therapy
We read with interest the recent article by Dr Chawla and colleagues showing that a furosemide stress test was able to predict the development of renal damage stage III according to the Acute Kidney Injury Network classification in critically ill patients [1]. In this study, 25 patients that subsequently developed acute kidney injury (AKI) had lower urine output 2 hours following administration...
متن کاملRenal prostacyclin influences renal function in non-azotemic cirrhotic patients treated with furosemide.
The influence of prostaglandins on renal function changes induced by furosemide was analyzed in 21 non-azotemic cirrhotic patients with ascites. Patients were studied in two periods of 120 min immediately before and after furosemide infusion (20 mg, ev). Furosemide caused an increase in creatinine clearance in 15 patients (group A: 99 +/- 7 vs. 129 +/- 5 ml/min; mean +/- S.E.) and a reduction i...
متن کاملThe influence of moderate hypoalbuminaemia on the renal metabolism and dynamics of furosemide in the rabbit.
1. The present study aimed to investigate the influence of hypoalbuminaemia on the pharmacokinetics and pharmacodynamics of furosemide. Hypoalbuminaemia was produced by repeated plasmapheresis, to attain plasma albumin concentrations of 21.6 +/- 0.9 g l-1, compared with 33.0 +/- 0.6 g l-1 in controls (P < 0.001). The per cent of bound furosemide in hypoalbuminaemic rabbits (90.8 +/- 0.7%) was l...
متن کاملRole of plasma protein binding on renal metabolism and dynamics of furosemide in the rabbit.
To investigate the influence of furosemide plasma protein binding on its kinetics and dynamics, the kinetics of furosemide was studied in the presence of a protein binding displacer, warfarin, and in hypoalbuminemic rabbits. Compared with controls, in anesthetized rabbits pretreated with warfarin, the unbound fraction of furosemide increased from 1.8 +/- 0.4% to 7.0 +/- 0.4% (p <.001), and its ...
متن کاملRenal function and renin secretion after administration of ouabain and ouabain plus furosemide in conscious sheep.
The effects of ouabain or ouabain and furosemide on renal function and renin secretion were studied in conscious isovolemic sheep. The sheep received a continuous renal arterial infusion of papaverine, 7 mg/min, throughout the experiment. Ouabain alone (7 X 10(-7) M in the renal plasma) produced significant decreases in glomerular filtration rate (GFR) and renal plasma flow (RPF) but not in ren...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1979
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)66343-2